Description

Methyl 4-(1-Acetylpiperidin-4-Yl)-3-(Trifluoromethyl)Benzoate is a high-value, advanced pharmaceutical intermediate characterized by its piperidine and trifluoromethyl benzoate structure. This compound is essential for research and development in medicinal chemistry, particularly for synthesizing novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of specific enzymes, leveraging the piperidine and trifluoromethyl motifs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for producing complex, high-purity molecules for preclinical and clinical trials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of investigational new drugs.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	Methyl 4-(1-Acetylpiperidin-4-Yl)-3-(Trifluoromethyl)Benzoate
CAS No.	1204331-63-4
Molecular Formula	C16H18F3NO3
Molecular Weight	329.32 g/mol
Synonyms	Methyl 4-(1-acetyl-4-piperidinyl)-3-(trifluoromethyl)benzoate; 4-(1-Acetylpiperidin-4-yl)-3-(trifluoromethyl)benzoic acid methyl ester; Benzoic acid, 4-(1-acetyl-4-piperidinyl)-3-(trifluoromethyl)-, methyl ester; 1204331-63-4; Methyl 4-(1-acetylpiperidin-4-yl)-3-(trifluoromethyl)benzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(1-Acetylpiperidin-4-Yl)-3-(Trifluoromethyl)Benzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various internal specifications and support customer audits for quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.