Description

2-Aminomethyl-3,5-Difluoropyridine Dihydrochloride is a high-purity, functionalized pyridine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by research institutions and industrial manufacturers in the life sciences sector for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the aminomethyl-difluoropyridine moiety into novel molecular scaffolds.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents and pesticides, leveraging its fluorine-substituted heterocyclic structure.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its chelating amine functionality.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex heterocycles.

Basic Information

Product Name	2-Aminomethyl-3,5-Difluoropyridine Dihydrochloride
CAS No.	1204298-48-5
Molecular Formula	C7H9Cl2F2N2
Molecular Weight	239.06 g/mol
Synonyms	(3,5-Difluoropyridin-2-yl)methanamine dihydrochloride; 2-(Aminomethyl)-3,5-difluoropyridine dihydrochloride; 3,5-Difluoro-2-pyridinemethanamine dihydrochloride; 2-Pyridinemethanamine, 3,5-difluoro-, dihydrochloride; 2-Aminomethyl-3,5-difluoropyridine HCl salt
EINECS	Contact for details

Quality Control

Our 2-Aminomethyl-3,5-Difluoropyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.