Description

1,2,3,4-Tetrahydro-1,6-Naphthyridin-8-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the naphthyridine class of heterocyclic compounds. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of innovative therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• Kinase Inhibitor Synthesis: Used in the construction of core scaffolds for potential kinase inhibitor therapies targeting various cancers.
• CNS Drug Discovery: Serves as a building block for compounds being investigated for neurological and psychiatric conditions.
• Chemical Biology Research: Employed as a probe or tool compound in biochemical and pharmacological studies.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke organic synthesis.
• Academic Research: Utilized in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	1,2,3,4-Tetrahydro-1,6-Naphthyridin-8-Amine
CAS No.	1204297-84-6
Molecular Formula	C8H11N3
Molecular Weight	149.19 g/mol
Synonyms	8-Amino-1,2,3,4-tetrahydro-1,6-naphthyridine; 1,6-Naphthyridin-8-amine, 1,2,3,4-tetrahydro-; 1,2,3,4-Tetrahydro-1,6-naphthyridin-8-ylamine; 1,2,3,4-Tetrahydro[1,6]naphthyridin-8-amine; 8-Amino-1,2,3,4-tetrahydro[1,6]naphthyridine; THN-8-Amine; 1204297-84-6
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-1,6-Naphthyridin-8-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and rigorous regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.