Description

1-(5-Bromopyridin-3-Yl)-2,2,2-Trifluoroethanol is a high-value brominated and fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a trifluoroethanol side chain, makes it an essential intermediate for introducing specific functionalities into target molecules. This compound is primarily utilized by research institutions and industrial R&D departments engaged in the development of novel pharmaceuticals, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and fluorine motifs.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Building block for synthesizing advanced polymers, liquid crystals, and electronic materials where fluorine incorporation enhances stability and performance.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in multi-step custom synthesis projects.

Basic Information

Product Name	1-(5-Bromopyridin-3-Yl)-2,2,2-Trifluoroethanol
CAS No.	1204234-60-5
Molecular Formula	C7H5BrF3NO
Molecular Weight	256.02 g/mol
Synonyms	5-Bromo-3-(2,2,2-trifluoro-1-hydroxyethyl)pyridine; 2,2,2-Trifluoro-1-(5-bromo-3-pyridinyl)ethanol; 1-(5-Bromo-3-pyridinyl)-2,2,2-trifluoroethanol; 3-(2,2,2-Trifluoro-1-hydroxyethyl)-5-bromopyridine; 5-Bromo-3-(trifluoro(hydroxy)methyl)pyridine; (5-Bromopyridin-3-yl)(trifluoro)methanol (tautomeric form); 1204234-60-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, providing full transparency on specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong alkalis and other incompatible materials as indicated by its fluoride/strong alkali property classification.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.