Description

5-Bromo-2-[(trifluoromethyl)thio]pyridine is a high-value, multi-functional heterocyclic building block featuring both bromine and a trifluoromethylthio substituent. This compound is strategically important for introducing the highly lipophilic and metabolically stable SCF₃ group into target molecules, a key modification in modern medicinal chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the SCF₃ group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.

Basic Information

Product Name	5-Bromo-2-[(trifluoromethyl)thio]pyridine
CAS No.	1204234-35-4
Molecular Formula	C₆H₃BrF₃NS
Molecular Weight	258.06 g/mol
Synonyms	2-Bromo-5-[(trifluoromethyl)thio]pyridine; 5-Bromo-2-(trifluoromethylsulfanyl)pyridine; 5-Bromo-2-(trifluoromethylthio)pyridine; Pyridine, 5-bromo-2-[(trifluoromethyl)thio]-; 1204234-35-4
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-[(trifluoromethyl)thio]pyridine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.