Description

1,2-Dihydro-5-Iodo-6-Isopropyl-2-Oxonicotinonitrile, 3-Cyano-5-Iodo-6-Isopropylpyridin-2(1H)-One is a high-value, functionalized pyridinone derivative that serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its unique structure, featuring both cyano and iodo substituents, makes it an essential precursor for constructing complex molecules in medicinal chemistry and materials science. This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides due to its bioactive pyridinone core.
• Organic Synthesis Reagent: Serves as a versatile precursor for cross-coupling reactions (e.g., Suzuki, Sonogashira) leveraging the reactive iodo group.
• Material Science Research: A precursor for creating functionalized polymers and liquid crystals with specific electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis Projects: Employed by contract research organizations (CROs) and CDMOs for client-specific molecule construction.

Basic Information

Item	Details
Product Name	1,2-Dihydro-5-Iodo-6-Isopropyl-2-Oxonicotinonitrile, 3-Cyano-5-Iodo-6-Isopropylpyridin-2(1H)-One
CAS No.	1203898-26-3
Molecular Formula	C10H10IN2O
Molecular Weight	301.11 g/mol
Synonyms	5-Iodo-6-isopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile; 3-Cyano-5-iodo-6-isopropylpyridin-2(1H)-one; 5-Iodo-6-isopropyl-2-oxo-1,2-dihydronicotinonitrile; 6-Isopropyl-5-iodopyridin-2(1H)-one-3-carbonitrile; 1203898-26-3 (CAS Name); 3-Cyano-5-iodo-6-(propan-2-yl)pyridin-2(1H)-one; 5-Iodo-6-(1-methylethyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with ICH guidelines and can tailor specifications to meet the requirements of cGMP for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.