Description

7-Methyl-2,7-diazaspiro[4.5]decan-6-one hydrochloride is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic diazepanone class. This compound is of significant commercial interest due to its critical role as a key building block in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the development of complex small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potent, selective drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns for constructing complex molecular architectures with improved pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed as a component in the linker or warhead design for novel bifunctional degrader molecules.
• CNS Drug Discovery: A valuable scaffold for developing new compounds aimed at neurological and psychiatric disorders.
• Oncology Research: Utilized in the synthesis of potential kinase inhibitors or other targeted cancer therapies.
• Contract Manufacturing: Supplied to CMOs for scale-up under cGMP conditions for clinical trial material and commercial API production.
• Chemical Reference Standard: Provided as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	7-Methyl-2,7-diazaspiro[4.5]decan-6-one hydrochloride
CAS No.	1203797-13-0
Molecular Formula	C9H17N2O·HCl
Molecular Weight	204.71 g/mol
Synonyms	7-Methyl-2,7-diazaspiro[4.5]decan-6-one HCl; 7-Methyl-2,7-diazaspiro[4.5]decan-6-one hydrochloride; 7-Methyl-2,7-diazaspiro[4.5]decan-6-one monohydrochloride; 6-Oxo-7-methyl-2,7-diazaspiro[4.5]decane hydrochloride; 1203797-13-0; 7-Methyl-2,7-diazaspiro[4.5]decan-6-one (Saltdata: HCl)
EINECS	Contact for details

Quality Control

Our 7-Methyl-2,7-diazaspiro[4.5]decan-6-one hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.