Description

2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-7'-Carbonitrile is a sophisticated spirocyclic organic compound featuring a fused isoquinoline and cyclopropane structure, serving as a critical advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. Its unique molecular architecture makes it invaluable for constructing complex molecules, particularly in the development of new active pharmaceutical ingredients (APIs) and bioactive compounds. This high-purity intermediate is essential for research and production in pharmaceutical R&D, agrochemical synthesis, and material science, where precise chemical functionality is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used as a building block for developing new generation pesticides and herbicides with specific modes of action.
• Organic Synthesis: Serves as a versatile spirocyclic scaffold in academic and industrial research for constructing complex heterocycles.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Potential use in the synthesis of organic semiconductors and advanced polymeric materials.
• Chemical Biology Probe: Utilized in the design of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-7'-Carbonitrile
CAS No.	1203686-91-2
Molecular Formula	C12H10N2
Molecular Weight	182.22 g/mol
Synonyms	7-Cyano-2,3-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]; Spiro[cyclopropane-1,4'-isoquinoline]-7'-carbonitrile, 2',3'-dihydro-1'H-; 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-7'-carbonitrile, 2',3'-dihydro-; 2,3-Dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-7'-carbonitrile; Spirocyclic Isoquinoline Carbonitrile; CAS 1203686-91-2
EINECS	Contact for details

Quality Control

Our 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-7'-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring suitability for use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.