Description

Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-6'-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. Its unique spirocyclic structure makes it a valuable building block for the synthesis of novel bioactive compounds targeting the central nervous system. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for neurological and psychiatric disorders.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for neurological targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for studying spirocyclic compound chemistry and pharmacology.
• Process Chemistry Development: Serves as a starting material for optimizing scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-6'-Carboxylate Hydrochloride
CAS No.	1203686-90-1
Molecular Formula	C14H16ClNO2
Molecular Weight	265.74 g/mol
Synonyms	Methyl 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-6'-carboxylate Hydrochloride; 6'-Methoxycarbonyl-1'H-spiro[cyclopropane-1,4'-isoquinoline] Hydrochloride; 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-6'-carboxylic Acid Methyl Ester Hydrochloride; CAS 1203686-90-1; Spiro[cyclopropane-1,4'-isoquinoline] Derivative; Methyl Spiro[cyclopropane-1,4'-isoquinoline]-6'-carboxylate HCl
EINECS	Contact for details

Quality Control

Our Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-6'-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.