Description

Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-7'-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and isoquinoline-based molecular architecture. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily sought after by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly those targeting neurological or oncological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, constrained spirocyclic structure.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic compounds for academic and industrial research.
• Process Development: Serves as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Potential use in developing probes for studying biological targets and mechanisms of action.

Basic Information

Product Name	Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-7'-Carboxylate Hydrochloride
CAS No.	1203685-29-3
Molecular Formula	C14H16ClNO2
Molecular Weight	265.74 g/mol
Synonyms	7'-Carbomethoxy-1',2',3',4'-tetrahydrospiro[cyclopropane-1,8'-isoquinoline] hydrochloride; Methyl 1,2,3,4-tetrahydrospiro[isoquinoline-8,1'-cyclopropane]-7-carboxylate hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline]-7'-carboxylic acid, 2',3'-dihydro-1'H-, methyl ester, hydrochloride; 1203685-29-3; Methyl 2,3-dihydro-1H-spiro[cyclopropane-1,4'-isoquinoline]-7'-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-7'-Carboxylate Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤3.0%; Any single impurity ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.