Description

Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-5'-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and isoquinoline-based molecular architecture. This compound is of significant value in medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly those with potential neurological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Academic Research: Employed in university and institutional labs for studying synthetic methodologies involving spirocyclic and fused heterocyclic systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's outsourced discovery and early-phase development work.
• Chemical Library Synthesis: A valuable component for building diverse screening libraries aimed at identifying new hits for biological targets.

Basic Information

Product Name	Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-5'-Carboxylate Hydrochloride
CAS No.	1203684-69-8
Molecular Formula	C14H16ClNO2
Molecular Weight	265.73 g/mol
Synonyms	Methyl 1'H-spiro[cyclopropane-1,4'-isoquinoline]-5'-carboxylate hydrochloride; 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-5'-carboxylic acid, 2',3'-dihydro-, methyl ester, hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline] derivative; CAS 1203684-69-8; 5'-Methoxycarbonyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-5'-Carboxylate Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards expected for pharmaceutical research materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.