Description

2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-8'-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and isoquinoline-based molecular architecture. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening for drug discovery programs.
• CNS Drug Development: Employed in the synthesis of potential therapeutics targeting neurological disorders due to its privileged isoquinoline structure.
• Kinase Inhibitor Synthesis: Acts as a building block for creating novel molecules designed to modulate kinase activity in oncology and inflammatory disease research.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying enzyme function and cellular pathways.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines where applicable.

Basic Information

Product Name	2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-8'-Carbonitrile Hydrochloride
CAS No.	1203683-22-0
Molecular Formula	C13H13ClN2
Molecular Weight	232.71 g/mol
Synonyms	8'-Cyano-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline] hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline]-8'-carbonitrile, 2',3'-dihydro-1'H-, hydrochloride; 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-8'-carbonitrile, 2',3'-dihydro-, hydrochloride; CAS 1203683-22-0
EINECS	Contact for details

Quality Control

Every batch of 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-8'-Carbonitrile Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.