Description

Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-8'-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and isoquinoline-based molecular architecture. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, including potential neuroactive drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those with potential neurological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex, constrained spirocyclic structure.
• Chemical Biology Probes: Serves as a core scaffold for developing molecular probes to study biological pathways and enzyme functions.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a sophisticated, functionalized isoquinoline derivative.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces in heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies in preclinical and early-phase development.

Basic Information

Product Name	Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-8'-Carboxylate Hydrochloride
CAS No.	1203683-18-4
Molecular Formula	C14H16ClNO2
Molecular Weight	265.73 g/mol
Synonyms	Methyl 1'H-spiro[cyclopropane-1,4'-isoquinoline]-8'-carboxylate hydrochloride; 8'-Methoxycarbonyl-1'H-spiro[cyclopropane-1,4'-isoquinoline] hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline]-8'-carboxylic acid methyl ester hydrochloride; 1'H-Spiro[cyclopropane-1,4'-isoquinoline]-8'-carboxylic acid, methyl ester, hydrochloride; Methyl 2,3-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-8'-carboxylate HCl
EINECS	Contact for details

Quality Control

Our production of Methyl 2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]-8'-Carboxylate Hydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting research-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency for your critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.