Description

7'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and trifluoromethylated isoquinoline scaffold. This compound matters for its critical role in modern medicinal chemistry, where its structural complexity enables the development of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve pharmacokinetic properties.
• Agrochemical Development: Serves as a precursor for creating new active ingredients with potential herbicidal or insecticidal activity, leveraging the stability of the trifluoromethyl group.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological pathways due to its distinctive three-dimensional structure.
• Material Science Research: Potential monomer or additive for specialty polymers where the spirocyclic unit can impart rigidity and unique physical properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.

Basic Information

Item	Detail
Product Name	7'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline]
CAS No.	1203683-05-9
Molecular Formula	C13H12F3N
Molecular Weight	239.24 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,4'-isoquinoline], 7'-(trifluoromethyl)-2',3'-dihydro-; 7-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclopropane]; Spiro[cyclopropane-1,4'-isoquinoline], 7'-(trifluoromethyl)-2',3'-dihydro-1'H-; 1203683-05-9; 7'-Trifluoromethyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]; 7-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[cyclopropane-1,4-isoquinoline]; 7'-(Trifluoromethyl)-1'H-spiro[cyclopropane-1,4'-isoquinoline]-2',3'-dihydro
EINECS	Contact for details

Quality Control

Our 7'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.