Description

6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and isoquinoline scaffold. This compound is valued for its structural complexity and the presence of a trifluoromethyl group, which is a critical motif for modulating the pharmacokinetic and metabolic properties of drug candidates. It is primarily utilized by medicinal chemists and process development scientists in the research and synthesis of novel bioactive molecules targeting the central nervous system and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Process Chemistry & Scale-up: Serves as a critical intermediate in the development of scalable synthetic routes for preclinical and clinical candidate molecules.
• Library Synthesis: Employed in the generation of focused compound libraries for high-throughput screening in drug discovery.
• Biochemical Probe Development: Can be utilized to create tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] Hydrochloride
CAS No.	1203682-82-9
Molecular Formula	C13H13ClF3N
Molecular Weight	275.70 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,4'-isoquinoline], 2',3'-dihydro-6'-(trifluoromethyl)-, hydrochloride (1:1); 6'-(Trifluoromethyl)-2',3'-dihydrospiro[cyclopropane-1,4'-isoquinoline] hydrochloride; Spiro[cyclopropane-1,4'-isoquinoline], 2',3'-dihydro-6'-(trifluoromethyl)-, hydrochloride; 1203682-82-9; 6-(Trifluoromethyl)-1,2,3,4-tetrahydrospiro[isoquinoline-4,1'-cyclopropane] hydrochloride
EINECS	Contact for details

Quality Control

Our 6'-(Trifluoromethyl)-2',3'-Dihydro-1'H-Spiro[Cyclopropane-1,4'-Isoquinoline] Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.