Description

2-Oxo-1-(2,2,2-Trifluoroethyl)-1,2-Dihydropyridine-4-Carboxylic Acid is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting a range of therapeutic areas. Pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers need this precise chemical to incorporate the unique physicochemical properties imparted by the trifluoroethyl and carboxylic acid functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, especially those requiring a fluorinated pyridone core for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve lipophilicity and biological activity.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized ligands for metal-catalyzed reactions, leveraging the carboxylic acid group for coordination.
• Material Science Precursor: Potential use in the synthesis of functionalized polymers or organic electronic materials due to its conjugated system and reactive handles.

Basic Information

Product Name	2-Oxo-1-(2,2,2-Trifluoroethyl)-1,2-Dihydropyridine-4-Carboxylic Acid
CAS No.	1203544-08-4
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	1,2-Dihydro-2-oxo-1-(2,2,2-trifluoroethyl)-4-pyridinecarboxylic Acid; 4-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-1-(2,2,2-trifluoroethyl)-; 1-(2,2,2-Trifluoroethyl)-2-oxo-1,2-dihydropyridine-4-carboxylic Acid; 2-Oxo-1-(trifluoroethyl)-1,2-dihydropyridine-4-carboxylic Acid; 4-Carboxy-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one; Trifluoroethyl DHP Carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Oxo-1-(2,2,2-Trifluoroethyl)-1,2-Dihydropyridine-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.