Description

2-Chloro-5-Methyl-3-[(Trimethylsilyl)-Ethynyl]Pyridine is a high-value, functionalized pyridine derivative featuring both a chloro and a trimethylsilyl-protected ethynyl group, making it a versatile and reactive building block for advanced synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture in complex chemical development. It is primarily utilized in pharmaceutical research, agrochemical development, and the synthesis of specialty materials and ligands.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Serves as a crucial precursor in the creation of advanced herbicides, fungicides, and insecticides with tailored activity profiles.
• Material Science: Used in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its conjugated ethynyl system.
• Catalyst & Ligand Development: The pyridine core and ethynyl group make it a valuable starting point for designing novel ligands in transition metal catalysis.
• Cross-Coupling Reactions: The chloro and ethynyl groups are ideal handles for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to build complex molecular structures.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Item	Detail
Product Name	2-Chloro-5-Methyl-3-[(Trimethylsilyl)-Ethynyl]Pyridine
CAS No.	1203499-58-4
Molecular Formula	C11H14ClNSi
Molecular Weight	223.77 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]-2-chloro-5-methylpyridine; 2-Chloro-5-methyl-3-(trimethylsilylethynyl)pyridine; 2-Chloro-5-methyl-3-(2-trimethylsilylethynyl)pyridine; 2-Chloro-5-methyl-3-(trimethylsilyl)ethynylpyridine; 2-Chloro-5-methylpyridin-3-yl(trimethylsilyl)acetylene; (2-Chloro-5-methyl-3-pyridinyl)(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methyl-3-[(Trimethylsilyl)-Ethynyl]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.