Description

n-(2-Chloro-6-((3-(Hydroxymethyl)Pyrrolidin-1-Yl)-Methyl)Pyridin-3-Yl)Pivalamide is a sophisticated heterocyclic organic compound featuring a pivalamide group and a substituted pyrrolidine-pyridine scaffold. This molecule is of significant interest as a key pharmaceutical intermediate or active pharmaceutical ingredient (API) building block in medicinal chemistry research and development. Its unique structure makes it a valuable precursor for synthesizing novel therapeutic agents, particularly targeting neurological and oncological pathways. This high-purity compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic molecules.
• Process Development & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme inhibition or receptor modulation.
• Custom Synthesis: Acts as a starting material for the custom synthesis of more complex, proprietary compounds for client-specific R&D projects.

Basic Information

Product Name	n-(2-Chloro-6-((3-(Hydroxymethyl)Pyrrolidin-1-Yl)-Methyl)Pyridin-3-Yl)Pivalamide
CAS No.	1203499-44-8
Molecular Formula	C16H24ClN3O2
Molecular Weight	325.84 g/mol
Synonyms	Pivalamide, N-[2-chloro-6-[[(3-hydroxymethyl)-1-pyrrolidinyl]methyl]-3-pyridinyl]-; 2-Chloro-6-((3-(hydroxymethyl)pyrrolidin-1-yl)methyl)nicotinamide, N-tert-butyl-; 1203499-44-8; Tert-butylamide of 2-chloro-6-((3-(hydroxymethyl)pyrrolidin-1-yl)methyl)nicotinic acid; N-(2-Chloro-6-(((3-(hydroxymethyl)pyrrolidin-1-yl)methyl)pyridin-3-yl)pivalamide
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-6-((3-(Hydroxymethyl)Pyrrolidin-1-Yl)-Methyl)Pyridin-3-Yl)Pivalamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.