Description

6-((Trimethylsilyl)Ethynyl)-1H-Pyrido-[2,3-B][1,4]Oxazin-2(3H)-One is a specialized heterocyclic building block featuring a trimethylsilyl-protected alkyne group, which is a valuable synthetic handle for further functionalization. This compound is of significant interest in medicinal chemistry and pharmaceutical research for the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing kinase inhibitory activity.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its fused heterocyclic core.
• Chemical Biology Probe Synthesis: The protected alkyne moiety allows for efficient conjugation via click chemistry (e.g., CuAAC) to create labeled probes for target identification and validation.
• Material Science: Potential building block for organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and functional group versatility.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploring new synthetic pathways in heterocyclic chemistry.

Basic Information

Product Name	6-((Trimethylsilyl)Ethynyl)-1H-Pyrido-[2,3-B][1,4]Oxazin-2(3H)-One
CAS No.	1203499-42-6
Molecular Formula	C₁₂H₁₆N₂O₂Si
Molecular Weight	248.36 g/mol
Synonyms	6-((Trimethylsilyl)ethynyl)-3,4-dihydro-1H-pyrido[2,3-b][1,4]oxazin-2-one; 6-(Trimethylsilylethynyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one; 6-[(Trimethylsilyl)ethynyl]-3,4-dihydro-1H-pyrido[2,3-b][1,4]oxazin-2-one; TMS-Ethynyl Pyridoxazinone; Silyl-protected pyridoxazinone alkyne
EINECS	Contact for details

Quality Control

Our 6-((Trimethylsilyl)Ethynyl)-1H-Pyrido-[2,3-B][1,4]Oxazin-2(3H)-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for research and development. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. Certificates of Analysis (COA) are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.