Description

2-Chloro-4-Iodo-5-Methyl-3-(Trimethylsilyl)-Pyridine is a high-value, multi-functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen and silyl substitution pattern makes it an indispensable intermediate for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Used in the synthesis of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions.
• Ligand Synthesis: Intermediate for creating sophisticated nitrogen-containing ligands for catalysis.
• Chemical Biology: Useful as a probe or tag in bioconjugation and medicinal chemistry programs.

Basic Information

Product Name	2-Chloro-4-Iodo-5-Methyl-3-(Trimethylsilyl)-Pyridine
CAS No.	1203499-34-6
Molecular Formula	C9H13ClINSi
Molecular Weight	325.65 g/mol
Synonyms	3-(Trimethylsilyl)-2-chloro-4-iodo-5-methylpyridine; 2-Chloro-4-iodo-5-methyl-3-(trimethylsilyl)pyridine; 5-Methyl-2-chloro-4-iodo-3-(trimethylsilyl)pyridine; Pyridine, 2-chloro-4-iodo-5-methyl-3-(trimethylsilyl)-; TMS-protected halo-methylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Iodo-5-Methyl-3-(Trimethylsilyl)-Pyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.