Description

n-(4-Hydroxy-5-((Trimethylsilyl)Ethynyl)-Pyridin-3-Yl)Acetamide is a high-purity, functionalized pyridine derivative designed for advanced chemical synthesis. This compound matters as a critical building block and intermediate in the development of novel active pharmaceutical ingredients (APIs) and specialty materials. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and other targeted therapy programs.
• Agrochemical Synthesis: Used as a precursor for developing novel pesticides and herbicides with specific modes of action.
• Ligand and Catalyst Development: Serves as a functionalized scaffold for creating novel ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials and functional polymers due to its ethynyl and silyl protecting groups.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthetic routes and scale-up projects.

Basic Information

Product Name	n-(4-Hydroxy-5-((Trimethylsilyl)Ethynyl)-Pyridin-3-Yl)Acetamide
CAS No.	1203499-31-3
Molecular Formula	C12H16N2O2Si
Molecular Weight	248.36 g/mol
Synonyms	N-[4-Hydroxy-5-[(trimethylsilyl)ethynyl]-3-pyridinyl]acetamide; 5-((Trimethylsilyl)ethynyl)-4-hydroxynicotinamide (related); Acetamide, N-[4-hydroxy-5-[(trimethylsilyl)ethynyl]-3-pyridinyl]-; 3-Acetamido-5-((trimethylsilyl)ethynyl)pyridin-4-ol; TMS-Ethynyl Pyridine Acetamide Derivative; CAS 1203499-31-3
EINECS	Contact for details

Quality Control

Our n-(4-Hydroxy-5-((Trimethylsilyl)Ethynyl)-Pyridin-3-Yl)Acetamide is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.