Description

2-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-5-Fluoro-3-Iodopyridine is a sophisticated, multi-functional organic intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in its complex molecular architecture, which incorporates a fluorinated pyridine ring, a pyrrolidine scaffold, and a tert-butyldimethylsilyl (TBDMS) protecting group, making it a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries who are engaged in the discovery of new therapeutic agents, particularly those targeting the central nervous system or requiring advanced pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those containing fluorinated heterocycles.
• Medicinal Chemistry Research: Used as a key scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Employed in the process development and scale-up of new Active Pharmaceutical Ingredients (APIs), leveraging its protected alcohol functionality.
• Agrochemical Synthesis: Acts as a building block for developing advanced crop protection agents and pesticides with enhanced efficacy.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Details
Product Name	2-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-5-Fluoro-3-Iodopyridine
CAS No.	1203499-14-2
Molecular Formula	C16H26FIN2OSi
Molecular Weight	436.38 g/mol
Synonyms	5-Fluoro-3-iodo-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 2-[3-[(tert-Butyldimethylsilyloxy)methyl]pyrrolidin-1-yl]-5-fluoro-3-iodopyridine; TBDMS-protected fluoropyrrolidinyl iodopyridine; N/A
EINECS	Contact for details

Quality Control

Our production of 2-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-5-Fluoro-3-Iodopyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.