Description

5-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Chloro-3-Iodopyridine is a high-value, multi-functional heterocyclic building block designed for advanced pharmaceutical and agrochemical research. This compound matters because it integrates a protected alcohol, a pyrrolidine scaffold, and halogenated pyridine, offering versatile sites for further synthetic elaboration crucial for developing new active ingredients. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the synthesis of new-generation herbicides and pesticides, leveraging its halogenated pyridine core.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study biological pathways and protein functions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical suppliers offering bespoke synthesis services to the life sciences industry.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and organosilicon chemistry.

Basic Information

Product Name	5-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Chloro-3-Iodopyridine
CAS No.	1203499-04-0
Molecular Formula	C16H26ClIN2OSi
Molecular Weight	452.83 g/mol
Synonyms	2-Chloro-3-iodo-5-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 2-Chloro-3-iodo-5-(3-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)pyridine; 5-(3-((Tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Chloro-3-Iodopyridine; TBS-protected pyrrolidinyl chloroidopyridine; 1203499-04-0; 5-(3-(((tert-Butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)-2-chloro-3-iodopyridine
EINECS	Contact for details

Quality Control

Our 5-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-2-Chloro-3-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity consistent with cGMP guidelines for advanced intermediates. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and full spectroscopic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials such as fluorides and strong alkalis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.