Description

5-Bromo-2-Methyl-Benzoic Acid tert-Butyl Ester is a high-purity, versatile organic intermediate essential for advanced chemical synthesis. This compound is valued for its role as a protected carboxylic acid derivative, offering enhanced stability and reactivity control in complex reaction sequences. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the bromine and ester functionalities for structural diversification.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and liquid crystals with tailored optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a precursor for generating other functionalized benzoic acid derivatives in medicinal chemistry.
• Chemical Reference Standard: Used as a certified reference material (CRM) for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	5-Bromo-2-Methyl-Benzoic Acid tert-Butyl Ester
CAS No.	1202551-75-4
Molecular Formula	C₁₂H₁₅BrO₂
Molecular Weight	271.15 g/mol
Synonyms	tert-Butyl 5-bromo-2-methylbenzoate; 2-Methyl-5-bromobenzoic acid tert-butyl ester; Benzoic acid, 5-bromo-2-methyl-, 1,1-dimethylethyl ester; 5-Bromo-o-toluic acid tert-butyl ester; 5-Bromo-2-methylbenzoic acid 1,1-dimethylethyl ester; t-Butyl 5-bromo-2-methylbenzoate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methyl-Benzoic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.