Description

(S)-tert-Butyl 2-(5-Phenyl-1,3,4-Oxadiazol-2-Yl)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its core value lies in its defined stereochemistry and the versatile 1,3,4-oxadiazole pharmacophore, which is crucial for modulating biological activity and physicochemical properties in drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of potential active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Research: Used as a scaffold for constructing compound libraries in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The pyrrolidine-oxadiazole structure is relevant for designing inhibitors of various enzymes, including proteases and kinases.
• Ligand Synthesis: Can be utilized in the preparation of chiral ligands for asymmetric catalysis.
• Agrochemical Research: Acts as an intermediate in the development of new agrochemicals with enhanced efficacy and selectivity.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or organic electronic materials due to its rigid, conjugated structure.

Basic Information

Product Name	(S)-tert-Butyl 2-(5-Phenyl-1,3,4-Oxadiazol-2-Yl)Pyrrolidine-1-Carboxylate
CAS No.	1201915-85-6
Molecular Formula	C₁₇H₂₁N₃O₃
Molecular Weight	315.37 g/mol
Synonyms	1-(1,1-Dimethylethyl) (2S)-2-(5-phenyl-1,3,4-oxadiazol-2-yl)-1-pyrrolidinecarboxylate; (S)-1-Boc-2-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrrolidine; Boc-L-2-(5-Phenyl-1,3,4-oxadiazol-2-yl)pyrrolidine; tert-Butyl (S)-2-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrrolidine-1-carboxylate; (S)-N-Boc-2-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-pyrrolidine; (S)-tert-Butyl 2-(5-phenyl-1,3,4-oxadiazol-2-yl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-(5-Phenyl-1,3,4-Oxadiazol-2-Yl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.