Description

2-Carboxy-3-Chloro-5-Cyanopyridine, 6-Carboxy-5-Chloropyridine-3-Carbonitrile, 3-Chloro-5-Cyanopicolinic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring both carboxylic acid and nitrile functional groups on a chlorinated pyridine core, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system or possessing kinase inhibitory activity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine scaffold.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Chemical Biology Probes: Utilized as a core structure for developing fluorescent tags, enzyme inhibitors, and other molecular probes for biochemical research.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Carboxy-3-Chloro-5-Cyanopyridine, 6-Carboxy-5-Chloropyridine-3-Carbonitrile, 3-Chloro-5-Cyanopicolinic Acid
CAS No.	1200497-81-9
Molecular Formula	C7H3ClN2O2
Molecular Weight	182.56 g/mol
Synonyms	3-Chloro-5-cyanopicolinic acid; 5-Chloro-6-cyanopyridine-2-carboxylic acid; 2-Carboxy-3-chloro-5-cyanopyridine; 6-Carboxy-5-chloronicotinonitrile; 5-Chloro-2-pyridinecarboxylic acid, 6-cyano-; 3-Chloro-5-cyano-2-pyridinecarboxylic acid; 5-Chloro-6-cyanopicolinic acid
EINECS	Contact for details

Quality Control

Our 2-Carboxy-3-Chloro-5-Cyanopyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.