Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Bromo-2-Methyl-1-(Phenylsulfonyl)-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and kinase inhibitor research. It is primarily sought by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors for developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Oncology Research: Used in the discovery and development of novel anti-cancer compounds due to its privileged scaffold.
• Chemical Biology: Serves as a probe or a tagged molecule for studying enzyme function and biological pathways.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for new chemical entities (NCEs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and API development.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry and heterocyclic chemistry studies.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Bromo-2-Methyl-1-(Phenylsulfonyl)-, Methyl Ester
CAS No.	1200130-72-8
Molecular Formula	C16H13BrN2O4S
Molecular Weight	409.26 g/mol
Synonyms	5-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 5-bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1-Tosyl-5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-bromo-2-methyl-1-(phenylsulfonyl)-, methyl ester; CAS 1200130-72-8
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Bromo-2-Methyl-1-(Phenylsulfonyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.