Description

((2R,3R,4R,5R)-3-(Benzoyloxy)-5-Bromo-4-Fluoro-4-Methyltetrahydrofuran-2-Yl)Methyl Benzoate is a high-purity, stereochemically defined nucleoside analog intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its precise molecular architecture, which is critical for the development of novel antiviral and anticancer therapeutics. It is primarily required by research institutions, custom synthesis laboratories, and pharmaceutical companies engaged in the development of next-generation nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of modified nucleoside analogs for antiviral and anticancer drug candidates.
• Antiviral Pro-drug Development: Used in research for constructing fluorinated and brominated nucleoside precursors, targeting viruses like hepatitis and influenza.
• Oncology Research: Serves as a critical intermediate for developing chemotherapeutic agents that incorporate halogenated sugar moieties to enhance metabolic stability and target specificity.
• Custom Organic Synthesis: Employed in contract research organizations (CROs) and CDMOs for the custom synthesis of complex, stereospecific molecules for client projects.
• Biochemical Tool Development: Utilized in creating labeled probes or inhibitors for studying enzymatic processes involving nucleotide metabolism.
• Process Chemistry & Scale-up: Acts as a reference standard or starting material for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	((2R,3R,4R,5R)-3-(Benzoyloxy)-5-Bromo-4-Fluoro-4-Methyltetrahydrofuran-2-Yl)Methyl Benzoate
CAS No.	1199809-24-9
Molecular Formula	C21H18BrFO5
Molecular Weight	449.27 g/mol
Synonyms	5'-O,3'-O-Dibenzoyl-5-bromo-4-fluoro-4-methyl-β-D-ribofuranose; 1-[(2R,3R,4R,5R)-3-(Benzoyloxy)-5-bromo-4-fluoro-4-methyloxolan-2-yl]methyl benzoate; 5-Bromo-4-fluoro-4-methyl-1,2,3-tri-O-benzoyl-β-D-ribofuranose (isomeric); Benzoyl-protected bromo-fluoro-methyl ribofuranose intermediate; Halogenated ribose derivative; Nucleoside synthon CAS 1199809-24-9
EINECS	Contact for details

Quality Control

Our production of ((2R,3R,4R,5R)-3-(Benzoyloxy)-5-Bromo-4-Fluoro-4-Methyltetrahydrofuran-2-Yl)Methyl Benzoate adheres to stringent quality protocols suitable for pharmaceutical intermediate applications. Each batch is characterized and tested to ensure high chiral purity and chemical identity. Comprehensive analytical methods including HPLC, NMR, and MS are employed. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.