Description

(S)-5-Methyl-4,7-Diazaspiro[2.5]Octan-6-One is a high-purity, chiral spirocyclic building block of significant interest in advanced pharmaceutical research and development. Its unique constrained spirocyclic structure makes it a valuable scaffold for designing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas. This compound is essential for research chemists and process development scientists in pharmaceutical and biotechnology companies seeking to explore new chemical space and improve the pharmacokinetic properties of lead molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and develop novel drug candidates.
• CNS Drug Discovery: Particularly valuable for research programs targeting neurological and psychiatric conditions due to its spirocyclic diaza structure.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial-scale production of chiral pharmaceuticals.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthetic transformations.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological targets and pathways.

Basic Information

Product Name	(S)-5-Methyl-4,7-Diazaspiro[2.5]Octan-6-One
CAS No.	1199792-85-2
Molecular Formula	C7H12N2O
Molecular Weight	140.18 g/mol
Synonyms	(S)-5-Methyl-4,7-diazaspiro[2.5]octan-6-one; (5S)-5-Methyl-4,7-diazaspiro[2.5]octan-6-one; 4,7-Diazaspiro[2.5]octan-6-one, 5-methyl-, (5S)-; (S)-5-Methyl-4,7-diaza-spiro[2.5]octan-6-one; Chiral Spirocyclic Lactam; (S)-enantiomer of 5-Methyl-4,7-diazaspiro[2.5]octan-6-one
EINECS	Contact for details

Quality Control

Our (S)-5-Methyl-4,7-Diazaspiro[2.5]Octan-6-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to industry best practices, and specifications can be tailored to meet specific project requirements, including those aligned with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.