Description

2-(4-Bromophenyl)-5,8-Dioxaspiro[3.4]Octane-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and brominated aromatic structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, leveraging the bioactivity of the bromophenyl and spirocyclic motifs.
• Material Science: Acts as a monomer or functional additive in the research of advanced polymers and liquid crystals, where its rigid structure can impart desired thermal and optical properties.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex heterocyclic compounds and natural product analogs via further functionalization of the carboxylic acid group.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	2-(4-Bromophenyl)-5,8-Dioxaspiro[3.4]Octane-2-Carboxylic Acid
CAS No.	1199586-87-2
Molecular Formula	C15H15BrO4
Molecular Weight	339.18 g/mol
Synonyms	2-(4-Bromophenyl)-5,8-dioxaspiro[3.4]octane-2-carboxylic acid; 5,8-Dioxaspiro[3.4]octane-2-carboxylic acid, 2-(4-bromophenyl)-; 4-Bromo-α-(5,8-dioxaspiro[3.4]oct-2-yl)benzenecarboxylic acid; 2-(p-Bromophenyl)-5,8-dioxaspiro[3.4]octane-2-carboxylic acid; Bromophenyl dioxaspirooctane carboxylic acid; BPDOCA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 2-(4-Bromophenyl)-5,8-Dioxaspiro[3.4]Octane-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We operate under a cGMP-compliant quality system to meet the rigorous standards of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.