Description

tert-Butyl 2-(4-Bromophenyl)-5,8-Dioxaspiro[3.4]Octan-2-Ylcarbamate CAS NO 1199557-05-5 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and carbamate-protected amine structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to construct sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) by introducing the bromophenyl and spirocyclic motifs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for new chemical entities under Good Manufacturing Practice (GMP) guidelines.
• Agrochemical Synthesis: Acts as a building block for creating novel compounds with potential herbicidal or insecticidal activity.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis, particularly in spirocycle formation and functional group manipulation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.

Basic Information

Product Name	tert-Butyl 2-(4-Bromophenyl)-5,8-Dioxaspiro[3.4]Octan-2-Ylcarbamate
CAS No.	1199557-05-5
Molecular Formula	C17H22BrNO4
Molecular Weight	384.27 g/mol
Synonyms	tert-Butyl N-[2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-yl]carbamate; 2-(4-Bromophenyl)-5,8-dioxaspiro[3.4]octane-2-carboxylic acid tert-butyl amide; BOC-Protected 2-(4-Bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine; (2-(4-Bromophenyl)-5,8-dioxaspiro[3.4]octan-2-yl)carbamic acid tert-butyl ester; 1199557-05-5; BOC-Spirocyclic Bromophenyl Intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(4-Bromophenyl)-5,8-Dioxaspiro[3.4]Octan-2-Ylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.