Description

tert-Butyl 5-Iodo-2,3-Dihydro-1H-Pyrido-[3,4-B][1,4]Oxazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure with a reactive iodine substituent. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

This specialized intermediate is designed for sophisticated synthetic applications, particularly in drug discovery and development.

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive iodine handle for cross-coupling reactions.
• Process Chemistry Development: Serves as a critical raw material in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.
• Academic Research: Employed in university and institutional labs for the development of new synthetic methodologies and novel heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 5-Iodo-2,3-Dihydro-1H-Pyrido-[3,4-B][1,4]Oxazine-1-Carboxylate
CAS No.	1198426-57-1
Molecular Formula	C12H15IN2O3
Molecular Weight	362.17 g/mol
Synonyms	1,1-Dimethylethyl 5-iodo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate; 5-Iodo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-iodo-3,4-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate; 5-Iodo-1,2,3,4-tetrahydro-pyrido[3,4-b][1,4]oxazine-1-carboxylic acid tert-butyl ester; Boc-protected 5-iodo-1,2,3,4-tetrahydro-pyrido[3,4-b][1,4]oxazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Iodo-2,3-Dihydro-1H-Pyrido-[3,4-B][1,4]Oxazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.