Description

(E)-Methyl 3-(2-Chloro-5-Methylpyridin-3-Yl)-Acrylate is a high-purity, versatile acrylate ester building block featuring a functionalized pyridine core. This compound matters as a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides.
• Material Science Research: Serves as a monomer or precursor for developing functional polymers with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to form complex biaryl systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(E)-Methyl 3-(2-Chloro-5-Methylpyridin-3-Yl)-Acrylate
CAS No.	1198401-58-9
Molecular Formula	C10H10ClNO2
Molecular Weight	211.64 g/mol
Synonyms	Methyl (2E)-3-(2-Chloro-5-methyl-3-pyridinyl)-2-propenoate; (E)-Methyl 3-(2-Chloro-5-methylpyridin-3-yl)acrylate; 2-Propenoic acid, 3-(2-chloro-5-methyl-3-pyridinyl)-, methyl ester, (2E)-; Methyl (E)-3-(2-chloro-5-methylpyridin-3-yl)acrylate; 3-(2-Chloro-5-methylpyridin-3-yl)acrylic acid methyl ester; (E)-3-(2-Chloro-5-methyl-3-pyridinyl)acrylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(2-Chloro-5-Methylpyridin-3-Yl)-Acrylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.