Description

tert-Butyl 8-Iodo-2,3-Dihydro-1H-Pyrido-[3,4-B][1,4]Oxazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and CNS drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Heterocyclic Compound Synthesis: Employed in the construction of fused pyrido-oxazine ring systems, which are privileged structures in medicinal chemistry.
• Labeled Compound Production: The iodine moiety provides a handle for further functionalization, including radioiodination for tracer studies or creating diagnostic agents.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel chemical entities.

Basic Information

Product Name	tert-Butyl 8-Iodo-2,3-Dihydro-1H-Pyrido-[3,4-B][1,4]Oxazine-1-Carboxylate
CAS No.	1198108-42-7
Molecular Formula	C12H13IN2O3
Molecular Weight	360.15 g/mol
Synonyms	1,4-Oxazine-1-carboxylic acid, 8-iodo-2,3-dihydro-, 1,1-dimethylethyl ester; 1-tert-Butyl 8-iodo-2,3-dihydro-1H-pyrido[3,4-b][1,4]oxazine-1-carboxylate; tert-Butyl 8-iodo-3,4-dihydro-2H-pyrido[3,4-b][1,4]oxazine-1(8H)-carboxylate; 8-Iodo-1,2,3,4-tetrahydro-pyrido[3,4-b][1,4]oxazine-1-carboxylic acid tert-butyl ester; tert-Butyl 8-iodo-3,4-dihydro-2H-pyrido[3,4-b][1,4]oxazine-1-carboxylate; CAS 1198108-42-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Iodo-2,3-Dihydro-1H-Pyrido-[3,4-B][1,4]Oxazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.