Description

tert-Butyl 3-(3-Hydroxyprop-1-ynyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a functionalized pyrrolopyridine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing small molecule drugs, particularly in oncology and CNS disorders. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of targeted kinase inhibitors and other bioactive molecules.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for novel drug discovery programs.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological pathways and protein function.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacology studies.

Basic Information

Item	Details
Product Name	tert-Butyl 3-(3-Hydroxyprop-1-ynyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.	1198106-25-0
Molecular Formula	C16H18N2O3
Molecular Weight	286.33 g/mol
Synonyms	1-Boc-3-(3-hydroxyprop-1-ynyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine; tert-Butyl 3-(3-hydroxypropynyl)-5-methylpyrrolo[2,3-b]pyridine-1-carboxylate; 5-Methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-(3-hydroxy-1-propyn-1-yl)-, 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-5-methyl-3-(3-hydroxyprop-1-yn-1-yl)-1H-pyrrolo[2,3-b]pyridine; Boc-Protected 3-alkynyl pyrrolopyridine derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(3-Hydroxyprop-1-ynyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.