Description

tert-Butyl 5-Methyl-3-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine core. This compound is specifically engineered for use in complex organic synthesis, particularly in the construction of kinase inhibitors and other biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and cellular pathways.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.

Basic Information

Product Name	tert-Butyl 5-Methyl-3-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
CAS No.	1198103-89-7
Molecular Formula	C19H26N2O2Si
Molecular Weight	342.51 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 5-methyl-3-[(trimethylsilyl)ethynyl]-, 1,1-dimethylethyl ester; 1-Boc-5-methyl-3-((trimethylsilyl)ethynyl)-7-azaindole; tert-Butyl 5-methyl-3-(trimethylsilylethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 5-Methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; 3-((Trimethylsilyl)ethynyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-Methyl-3-((Trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are fully characterized using advanced analytical techniques, including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and performance in sensitive synthetic applications.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.