Description

tert-Butyl 3-(Hydroxymethyl)-5-Methyl-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a versatile pyrrolopyridine scaffold. This compound matters for its critical role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. Pharmaceutical R&D and fine chemical manufacturers need this intermediate for developing new drug candidates, especially in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: Serves as a core structural motif for designing and synthesizing potent kinase inhibitors for therapeutic applications.
• Oncology Research Compounds: Used in the research and development of targeted cancer therapies due to its privileged heterocyclic structure.
• Medicinal Chemistry Scaffold: Provides a versatile platform for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Custom Synthesis Building Block: Employed by fine chemical suppliers for the contract manufacturing of specialized, high-value compounds.
• Bioconjugation & Probe Synthesis: The hydroxymethyl group offers a convenient handle for further functionalization, linking to other molecules, or creating diagnostic probes.

Basic Information

Product Name	tert-Butyl 3-(Hydroxymethyl)-5-Methyl-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate
CAS No.	1198103-73-9
Molecular Formula	C14H18N2O3
Molecular Weight	262.31 g/mol
Synonyms	1-Boc-3-(hydroxymethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine; 5-Methyl-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (hydrolysis product related); 3-(Hydroxymethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(hydroxymethyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-(hydroxymethyl)-5-methyl-, 1,1-dimethylethyl ester; Boc-3-(hydroxymethyl)-5-methyl-7-azaindole
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Hydroxymethyl)-5-Methyl-1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.