Description

1-(tert-Butoxycarbonyl)-5-Methyl-1H-Pyrrolo-[2,3-B]Pyridine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolopyridine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted small molecules.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of final Active Pharmaceutical Ingredients (APIs) requiring the pyrrolo[2,3-b]pyridine core structure.
• Bioconjugation & Probe Development: The carboxylic acid functionality allows for coupling reactions to create labeled probes or antibody-drug conjugates (ADCs) for diagnostic and therapeutic applications.
• Chemical Biology: Serves as a building block for creating chemical tools to study biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)-5-Methyl-1H-Pyrrolo-[2,3-B]Pyridine-3-Carboxylic Acid
CAS No.	1198097-92-5
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	5-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid, 1-(1,1-dimethylethyl) ester; 1-Boc-5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid; tert-Butyl 5-methyl-3-carboxy-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 1-(tert-Butoxycarbonyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid; 1-N-Boc-5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid; Boc-5-methyl-pyrrolo[2,3-b]pyridine-3-carboxylic acid.
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)-5-Methyl-1H-Pyrrolo-[2,3-B]Pyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored away from strong acids and organic solvents to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.