Description

tert-Butyl 3-Formyl-5-Methyl-1H-Pyrrolo-[2,3-B]Pyridine-1-Carboxylate is a high-value, multi-functional heterocyclic building block essential for modern pharmaceutical and agrochemical research. This compound serves as a critical synthetic intermediate, enabling the construction of complex molecular architectures through its reactive aldehyde and protected amine functionalities. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting cancer and inflammatory diseases.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its fused pyrrolopyridine scaffold.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes and tool compounds to study biological pathways.
• Material Science: Potential building block for advanced organic electronic materials due to its conjugated π-system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and advanced intermediates under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and medicinal chemistry.

Basic Information

Product Name	tert-Butyl 3-Formyl-5-Methyl-1H-Pyrrolo-[2,3-B]Pyridine-1-Carboxylate
CAS No.	1198097-53-8
Molecular Formula	C14H16N2O3
Molecular Weight	260.29 g/mol
Synonyms	1-Boc-3-formyl-5-methyl-1H-pyrrolo[2,3-b]pyridine; tert-Butyl 3-formyl-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 5-Methyl-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-aldehyde; 1-(tert-Butoxycarbonyl)-5-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde; 3-Formyl-5-methyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; Boc-3-CHO-5-Me-7-azaindole
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Formyl-5-Methyl-1H-Pyrrolo-[2,3-B]Pyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.