Description

4-Chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a halogenated pyrrolopyridine scaffold with a trifluoromethyl group, enabling precise molecular modifications to fine-tune the properties of target compounds. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in drug discovery programs targeting kinase inhibition and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents, leveraging the biological activity of the pyrrolopyridine core.
• Material Science Precursor: Serves as a building block for creating functional organic materials, such as ligands for catalysts or components in organic electronics.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1196507-58-0
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	4-Chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-(trifluoromethyl)-; 4-Chloro-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 4-Chloro-5-(trifluoromethyl)-7-azaindole; 5-(Trifluoromethyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We operate under a quality system designed to meet the rigorous standards required for pharmaceutical R&D and other critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.