Description

1H-Pyrrolo[2,3-B]Pyridin-3-Amine, 5-Chloro-4-Fluoro- is a high-purity, heterocyclic aromatic amine building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel, biologically active molecules, particularly kinase inhibitors. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing targeted therapies for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key synthon for the research and synthesis of novel small-molecule drugs, especially protein kinase inhibitors.
• Oncology Drug Discovery: Used in the development of targeted cancer therapies due to its privileged scaffold present in many kinase-targeting compounds.
• Chemical Biology Research: Employed as a probe or building block in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the multi-step synthesis of potential API candidates.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridin-3-Amine, 5-Chloro-4-Fluoro-
CAS No.	1196507-37-5
Molecular Formula	C7H5ClFN3
Molecular Weight	185.59 g/mol
Synonyms	5-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine; 5-Chloro-4-fluoro-3-amino-7-azaindole; 5-Chloro-4-fluoro-7-azaindol-3-ylamine; 5-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine; 3-Amino-5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-ylamine; 1196507-37-5; 5-Chloro-4-fluoro-7-azaindole-3-amine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridin-3-Amine, 5-Chloro-4-Fluoro- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Single unknown impurity ≤ 1.0% Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.