Description

(6-Chloromethyl-Pyridin-3-Yl)-Carbamic Acid tert-Butyl Ester is a high-value, protected pyridine derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its bifunctional structure, featuring both a chloromethyl group and a Boc-protected amine, makes it an essential building block for constructing complex molecules with precise regiochemistry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for creating advanced crop protection agents and herbicides with specific modes of action.
• Ligand and Catalyst Development: Used to construct sophisticated pyridine-based ligands for metal catalysis and organocatalysis.
• Chemical Biology Probes: Intermediate for labeling reagents, PROTACs (Proteolysis Targeting Chimeras), and other molecular tools.
• Material Science Research: Monomer or precursor for functionalized polymers and advanced organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	(6-Chloromethyl-Pyridin-3-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1196157-44-4
Molecular Formula	C11H15ClN2O2
Molecular Weight	242.70 g/mol
Synonyms	tert-Butyl N-(6-chloromethyl-3-pyridinyl)carbamate; 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-6-(chloromethyl)pyridine; Boc-3-Amino-6-chloromethylpyridine; N-Boc-3-Amino-6-chloromethylpyridine; 6-(Chloromethyl)-N-(tert-butoxycarbonyl)pyridin-3-amine; (6-Chloromethyl-3-pyridinyl)carbamic acid 1,1-dimethylethyl ester; 3-(Boc-amino)-6-chloromethylpyridine
EINECS	Contact for details

Quality Control

Our production of (6-Chloromethyl-Pyridin-3-Yl)-Carbamic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.