Description

2-Chloro-3-Ethynylpyridine is a high-value pyridine derivative and versatile chemical building block characterized by its reactive ethynyl and chloro substituents. This compound is essential for advanced organic synthesis, particularly in constructing complex molecular architectures for pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and the synthesis of novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its pyridine core for bioactivity.
• Material Science Precursor: Serves as a monomer or building block for advanced polymers, ligands for catalysis, and functionalized materials.
• Cross-Coupling Reactions: The chloro and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems due to its ability to undergo click chemistry via the alkyne group.
• Ligand Synthesis: Employed in the development of novel chelating ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Chloro-3-Ethynylpyridine
CAS No.	1196156-69-0
Molecular Formula	C7H4ClN
Molecular Weight	137.57 g/mol
Synonyms	3-Ethynyl-2-chloropyridine; 2-Chloro-3-ethynylpyridine; Pyridine, 2-chloro-3-ethynyl-; 2-Chloro-3-pyridylethyne
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Ethynylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.