Description

Methyl 3-Ethynylpicolinate is a high-value, functionalized heterocyclic building block featuring both an ethynyl group and an ester moiety. This unique molecular architecture makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors, targeted cancer therapies, and other small-molecule active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators requiring specific heterocyclic scaffolds.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, conductive materials, and metal-organic frameworks (MOFs).
• Click Chemistry Substrate: The terminal alkyne group is ideal for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and polymer functionalization.
• Ligand Synthesis: Used to prepare complex pyridine-based ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological processes.

Basic Information

Product Name	Methyl 3-Ethynylpicolinate
CAS No.	1196156-66-7
Molecular Formula	C9H7NO2
Molecular Weight	161.16 g/mol
Synonyms	3-Ethynylpyridine-2-carboxylic acid methyl ester; Methyl 3-ethynylpyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 3-ethynyl-, methyl ester; 3-Ethynylpicolinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Ethynylpicolinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.