Description

5-Ethynylpyridin-2-ol is a versatile pyridine derivative featuring both an ethynyl and a hydroxyl functional group, making it a valuable building block in advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel pharmaceuticals and agrochemicals, particularly as a key intermediate in the creation of targeted small-molecule inhibitors. It is primarily utilized by the pharmaceutical, agrochemical, and specialty chemical industries for research and development, process chemistry, and the production of active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of kinase inhibitors and other biologically active molecules for drug discovery and development.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Ligand for Catalysis: Acts as a building block for creating specialized ligands used in transition metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs) due to its acetylene moiety.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular processes.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production in fine chemical manufacturing.

Basic Information

Product Name	5-Ethynylpyridin-2-ol
CAS No.	1196156-05-4
Molecular Formula	C7H5NO
Molecular Weight	119.12 g/mol
Synonyms	2-Hydroxy-5-ethynylpyridine; 5-Ethynyl-2-pyridinol; 5-Ethynyl-2-hydroxypyridine; 2-Pyridinol, 5-ethynyl-; 5-Ethynylpyridin-2(1H)-one (tautomer)
EINECS	Contact for details

Quality Control

Our 5-Ethynylpyridin-2-ol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.