Description

5-Bromo-2-Trifluoromethyl-Nicotinic Acid Ethyl Ester is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its molecular structure, featuring both bromo and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of specialty chemicals, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: The bromine atom serves as an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse chemical libraries.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution on the physicochemical and biological properties of heterocyclic systems.

Basic Information

Product Name	5-Bromo-2-Trifluoromethyl-Nicotinic Acid Ethyl Ester
CAS No.	1196153-48-6
Molecular Formula	C9H7BrF3NO2
Molecular Weight	298.06 g/mol
Synonyms	Ethyl 5-Bromo-2-(trifluoromethyl)nicotinate; 5-Bromo-2-(trifluoromethyl)pyridine-3-carboxylic Acid Ethyl Ester; 3-Pyridinecarboxylic acid, 5-bromo-2-(trifluoromethyl)-, ethyl ester; Ethyl 5-bromo-2-(trifluoromethyl)pyridine-3-carboxylate; 5-Bromo-2-trifluoromethylnicotinic acid ethyl ester; 5-Bromo-2-trifluoromethyl-3-pyridinecarboxylic acid ethyl ester; 5-Bromo-2-trifluoromethyl-pyridine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-Trifluoromethyl-Nicotinic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our facilities operate under cGMP principles where applicable, ensuring traceability and reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.