Description

3-Ethynylisonicotinaldehyde is a versatile and highly functionalized pyridine derivative, characterized by its reactive aldehyde and ethynyl groups. This compound is of significant value as a key synthetic intermediate, enabling the construction of complex molecular architectures through reactions such as Sonogashira coupling, click chemistry, and reductive amination. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional ligands.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides that require specific pyridine-based scaffolds.
• Material Science Precursor: Serves as a monomer or cross-linker in the creation of advanced polymers, conductive materials, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: The alkyne group allows for bio-conjugation via click chemistry, making it useful for labeling and studying biological systems.
• Ligand Synthesis for Catalysis: Employed in the preparation of novel nitrogen-containing ligands for transition metal catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploring new chemical spaces in synthetic organic chemistry.

Basic Information

Product Name	3-Ethynylisonicotinaldehyde
CAS No.	1196153-32-8
Molecular Formula	C8H5NO
Molecular Weight	131.13 g/mol
Synonyms	4-Formyl-3-ethynylpyridine; 3-Ethynyl-4-pyridinecarboxaldehyde; 3-Ethynylisonicotinaldehyde; 3-Ethynyl-4-formylpyridine; Isonicotinaldehyde, 3-ethynyl-; Pyridine-4-carboxaldehyde, 3-ethynyl-
EINECS	Contact for details

Quality Control

Our 3-Ethynylisonicotinaldehyde is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for the production of materials intended for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.