Description

4-Ethynylpyridin-2(1H)-One is a versatile heterocyclic building block featuring both a pyridone core and a terminal alkyne functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry, particularly for applications in click chemistry, cross-coupling reactions, and the development of kinase inhibitors or other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with azides for bioconjugation and material science applications.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Ligand Synthesis: Serves as a precursor for creating complex ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into polymers and advanced materials to impart specific electronic or structural properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-Ethynylpyridin-2(1H)-One
CAS No.	1196152-08-5
Molecular Formula	C7H5NO
Molecular Weight	119.12 g/mol
Synonyms	4-Ethynyl-2(1H)-pyridinone; 4-Ethynyl-2-pyridone; 4-Ethynyl-1H-pyridin-2-one; 2-Hydroxy-4-ethynylpyridine; 4-Ethynylpyridin-2-ol; 4-Ethynyl-2-hydroxypyridine; Building Block 1196152-08-5
EINECS	Contact for details

Quality Control

Our 4-Ethynylpyridin-2(1H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.