Description

Methyl 3-(Chloromethyl)Picolinate is a high-purity, versatile pharmaceutical intermediate and organic building block. This compound is valued for its bifunctional reactivity, featuring both a chloromethyl group and an ester-protected carboxylic acid, making it a critical synthon for constructing complex heterocyclic systems. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and novel molecular entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its picolinate core structure.
• Chemical Research: Serves as a versatile precursor in medicinal chemistry and process chemistry for lead optimization and scale-up studies.
• Ligand and Chelator Development: The picolinate moiety is useful for creating novel ligands in coordination chemistry and catalyst design.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	Methyl 3-(Chloromethyl)Picolinate
CAS No.	1196146-77-6
Molecular Formula	C8H8ClNO2
Molecular Weight	185.61 g/mol
Synonyms	3-(Chloromethyl)picolinic acid methyl ester; Methyl 3-(chloromethyl)pyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 3-(chloromethyl)-, methyl ester; Methyl 3-chloromethylpicolinate
EINECS	Contact for details

Quality Control

Our Methyl 3-(Chloromethyl)Picolinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and advanced chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.