Description

4-Hydroxy-6-Trifluoromethyl-Pyridine-3-Carbaldehyde is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining an aldehyde functionality with a hydroxyl group and a trifluoromethyl substituent, makes it indispensable for creating novel compounds with tailored properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of functional organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Hydroxy-6-Trifluoromethyl-Pyridine-3-Carbaldehyde
CAS No.	1196146-48-1
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	6-(Trifluoromethyl)-4-oxo-1,4-dihydropyridine-3-carbaldehyde; 4-Hydroxy-6-(trifluoromethyl)nicotinaldehyde; 3-Formyl-4-hydroxy-6-(trifluoromethyl)pyridine; 4-Hydroxy-6-trifluoromethyl-3-pyridinecarboxaldehyde; 4-Hydroxy-6-trifluoromethylpyridine-3-carboxaldehyde; 1,4-Dihydro-4-oxo-6-(trifluoromethyl)-3-pyridinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-6-Trifluoromethyl-Pyridine-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.